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Problems may develop if topical steroids are used for long periods, or if short courses of stronger steroids are repeated often. Some patients continue to gain weight and the size of their breasts become larger. Also, some patients may want to discontinue use of oral steroids. Drug interactions with drugs used to treat breast cancer There are several drugs used to treat breast cancer that interact with estrogen. These include estrogen blockers (which decrease the effect of estrogen on breast cancer cells), aromatase inhibitors (which inhibit the aromatase enzyme and decrease the growth of breast cells), and progestin. Some medications use different mechanisms that may interact with estrogen. Patients taking estrogen blockers should be advised to discontinue the estrogen blockers for a 24-hour period before continuing with estrogen therapy. Patients who are taking estrogen-containing oral contraceptives (OCs) should be advised to discontinue use of an OC during first dose of oral estrogen and for a 24-hour period before continuing with oral estrogen therapy. The progestin, doxorubicin, may interfere with oral estrogen therapy and can result in weight gain and enlargement of the breast. When estrogen therapy is initiated, patients are encouraged to use breast implants. If breast implants are not possible, breast implants should be reapplied by the first dose of estrogen therapy and for a period of 4 weeks or more following subsequent doses. Similar articles:
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